Brugada syndrome is a very serious heart disorder and causes the rhythm or heartbeat to be too fast, too slow, or irregular. This condition makes the heart can not pump blood throughout the body optimally. If this happens, the impact will be very fatal and can threaten a person's life.
Brugada syndrome is one of the leading causes of sudden deaths among young people who are otherwise healthy and have no heart problems. More worryingly, the case of death caused by Brugada syndrome often occurs suddenly, without showing any symptoms at all.
Brugada syndrome is a rare disease, where the majority of sufferers are Japanese and Southeast Asian. Many suspect this disease is caused by genetic factors or family-derived diseases. The facts prove that the disease is more common in adolescent and adult males. This disease is rare in children.
Symptoms of Brugada Syndrome
As mentioned earlier, the occurrence of Brugada syndrome is often asymptomatic. This disease is generally only detected when a person performs an electrocardiogram (EKG) test. But in some people, Brugada syndrome can show symptoms that are not much different from other heart disease patients, among others:
- Shortness of breath
- Irregular heartbeat (palpitations)
- High fever
To prevent a fatal impact, call your doctor immediately if you suddenly experience one or more of the above.
Causes of Brugada Syndrome
Someone with Brugada syndrome has a normal structure or heart shape, but they have problems with ions that regulate electrical activity in the heart.
Each heart muscle cell has an ion channel that functions to drain compounds such as sodium, calcium, and potassium to get out and enter the heart muscle. These are the three ions that control the electrical performance of the heart, so the heart can contract and perform its function as a blood pumper in the body.
In Brugada syndrome, there is damage to the heart ion channel so that the electrical flow of the heart becomes irregular. As a result, the heart will contract with a very fast rhythm and the blood is not able to be pumped effectively throughout the body. If it happens for only a moment, the patient will usually faint or lose consciousness temporarily. But if this heart rhythm remains abnormal within a few minutes, the patient will have a heart attack.
Several studies have been developed to find out the genetic disorders underlying this disease. Nearly a third of cases of Brugada syndrome are caused by mutations in the SCN5A gene. Under normal conditions, this gene serves to regulate the flow of sodium ions in the heart. At the time of mutation, the amount of sodium ions will decrease so that the activity of heart contraction becomes disturbed.
In many cases, Brugada syndrome appears as a hereditary disease. But there are several other factors that can trigger this disease, including:
- Often use cocaine.
- Has a high calcium content in the blood.
- Use drugs to treat high blood pressure, depression, and chest pain.
Have potassium levels that are too high or too low.
Risk Factors Brugada Syndrome
The risk of developing Brugada syndrome may increase due to several things. The following are a number of factors that can trigger the appearance of Brugada syndrome:
- Descendants. If one of your family members has Brugada syndrome, you are also at risk of contracting the disease.